Drop penetration bar limits

Try out PMC Labs and tell us what you think. Learn More. There are more than recognized disorders of the eye. This makes the development of advanced ocular formulations an important topic in pharmaceutical science. One of the ways to improve drug delivery to the eye is the use of penetration enhancers.
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08.12.2020
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Drop impact printing

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Dynamic cone penetrometer

Try out PMC Labs and tell us what you think. Learn More. Ultrasonic liquid penetration ULP measurements of porous sheets have been applied for a variety of purposes ranging from determining liquid absorption dynamics to surface characterization of substrates. Interpretation of ULP results, however, is complex as the ultrasound signal can be affected by several mechanisms: 1 air being replaced by the liquid in the substrate pores, 2 air bubbles forming during penetration, and 3 structural changes of the substrate due to swelling of the substrate material. Analyzing tailored liquids and substrates in combination with contact angle measurements we are demonstrating that the characteristic shape of the ULP measurement curves can be interpreted in terms of the regime of liquid uptake. A fast and direct decline of the curve corresponds to capillary penetration, the slope of the curve indicates the penetration speed. A slow decline after a previous maximum in the signal can be related to diffusive liquid transport and swelling of the substrate material.
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Penetration Enhancers in Ocular Drug Delivery

It is important to realize that a lot of product type testing like helmet testing does not seek to precisely reproduce real life situations, rather it attempts to define a set of requirements that is analogous to the types of situations that might be encountered while engaged in a prescribed activity. Helmet tests are designed to be repeatable, measurable and include a fixed range of situations a helmet might reasonably encounter. At this point the concerns of helmet testing does not include responses of the neck or body as they react with the head during a crash.
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