The first narcosis with chloroform was performed by James Young Simpson on himself on November 4, Knowledge of the narcotic effect of chloroform spread rapidly, but very soon reports of sudden deaths mounted. The first fatality was a year-old girl called Hannah Greener, who died on January 28, The opponents and supporters of chloroform were mainly at odds with the question of whether the complications were solely due to respiratory disturbance or whether chloroform had a specific effect on the heart. Between and numerous commissions in UK studied chloroform, but failed to come to any clear conclusions. It was only in that Levy proved in experiments with animals that chloroform can cause cardiac fibrillation. The reservations about chloroform could not halt its soaring popularity.

NCBI Bookshelf. AEGLs represent threshold exposure limits for the general public and are applicable to emergency exposure periods ranging from 10 minute min to 8 hour h. The three AEGLs are defined as follows:. However, the effects are not disabling and are transient and reversible upon cessation of exposure.

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